If by this you mean no LED display on front of box, then I'm afraid it is a hardware problem and as advised above return for repair/refund/replacement.
Is the hard drive powered by the USB port or does it have a separate supply ? The USB port can only supply 500mA which is fine for a running drive, but the supply needed to spin up a drive can exceed 800mA. Your drive may have put a strain on the USB supply over time killing your box.
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